TY  - CHAP
M1  - Book, Section
TI  - Mixed Connective Tissue Disease & Overlap Syndromes
A1  - Yazdany, Jinoos
A1  - Manno, Rebecca L.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2022
T2  - Current Medical Diagnosis & Treatment 2022
AB  - Many  patients  with  symptoms  and  signs  of  a  connective  tissue  disease  have  features  of  more  than  one  type  of  rheumatic  disease.  Special  attention  has  been  drawn  to  a  subset  of  antinuclear  antibody–positive  patients  who  have  high  titers  of  RNP  autoantibodies  and  overlapping  features  of  SLE,  systemic  sclerosis,  rheumatoid  arthritis  and  inflammatory  myositis.  Swollen  or  puffy  hands  are  a  common  early  feature  of  this  disease,  referred  to  as  mixed  connective  tissue  disease.  Raynaud  phenomenon,  arthralgias,  and  myalgias  are  common.  Unlike  patients  with  SLE,  renal  or  central  nervous  system  disease  is  uncommon.  A  key  reason  to  identify  this  subset  of  patients  is  that  pulmonary  hypertension  and  interstitial  lung  disease  are  major  causes  of  mortality,  and  regular  screening  for  these  manifestations  is  required.  Some  patients  have  features  of  more  than  one  connective  tissue  disease  (eg,  rheumatoid  arthritis  and  SLE,  SLE  and  systemic  sclerosis)  in  the  absence  of  high-titer  anti-RNP  antibodies  and  are  referred  to  as  having  an  “overlap  syndrome.”  Treatments  are  guided  more  by  the  distribution  and  severity  of  patients’  organ  system  involvement  than  by  therapies  specific  to  these  overlap  syndromes.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184193217
ER  -