TY - CHAP M1 - Book, Section TI - Crystal Deposition Arthritis A1 - Yazdany, Jinoos A1 - Manno, Rebecca L. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - KEY CLINICAL UPDATES IN CRYSTAL DEPOSITION ARTHRITISIn a 2020 randomized, controlled trial in patients with CKD and a high risk of its progression, urate-lowering treatment with allopurinol did not slow the decline in eGFR when compared to placebo.In patients with concomitant coronary artery disease, long-term colchicine use can reduce major cardiovascular events.Despite initial concern that febuxostat was associated with more cardiovascular events than allopurinol, a large, randomized, controlled trial in 2020 showed that the two drugs have similar cardiovascular safety. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184192979 ER -