TY  - CHAP
M1  - Book, Section
TI  - Antibiotic Prophylaxis of Surgical Site Infections
A1  - Cheng, Hugo Q.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2022
T2  - Current Medical Diagnosis & Treatment 2022
AB  - Surgical  site  infection  is  estimated  to  occur  in  roughly  4%  of  general  or  vascular  operations.  Although  the  type  of  procedure  is  the  main  factor  determining  the  risk  of  developing  a  surgical  site  infection,  certain  patient  factors  have  been  associated  with  increased  risk,  including  diabetes  mellitus,  older  age,  obesity,  smoking,  heavy  alcohol  consumption,  admission  from  a  long-term  care  facility,  and  multiple  medical  comorbidities.  For  most  major  procedures,  the  use  of  prophylactic  antibiotics  has  been  demonstrated  to  reduce  the  incidence  of  surgical  site  infections.  Several  general  conclusions  can  be  drawn  from  studies  of  different  antibiotic  regimens  for  surgical  procedures.  First,  substantial  evidence  suggests  that  a  single  dose  of  an  appropriate  intravenous  antibiotic—or  combination  of  antibiotics—is  as  effective  as  multiple-dose  regimens  that  extend  into  the  postoperative  period.  Second,  for  most  procedures,  a  first-generation  cephalosporin  (eg,  cefazolin  2  g  intravenously)  is  as  effective  as  later-generation  agents.  Third,  prophylactic  antibiotics  should  be  given  intravenously  at  induction  of  anesthesia  or  roughly  30–60  minutes  prior  to  the  skin  incision.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/24
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184156231
ER  -