TY - CHAP M1 - Book, Section TI - Tularemia: Diseases Transmitted Primarily from Animals to Humans (Zoonoses) A1 - Mead, Paul S. A2 - Boulton, Matthew L. A2 - Wallace, Robert B. PY - 2022 T2 - Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e AB - Tularemia is an uncommon but potentially serious bacterial zoonosis caused by Francisella tularensis. Transmission to humans occurs through arthropod bites, ingestion of contaminated food or water, inhalation of contaminated aerosols, or handling of infected animal tissues. Clinical manifestations are variable and depend on the route of inoculation, the dose, and the virulence of the organism. Most commonly, the disease presents in humans as an indolent ulcer at the site of cutaneous inoculation accompanied by regional lymphadenitis (ulceroglandular form). Other forms include glandular, oculoglandular, oropharyngeal, gastrointestinal, septic, and pneumonic tularemia. Although uncommon, tularemia occurs widely in temperate and subarctic regions of North America and Eurasia. Currently in the United States, fewer than 200 cases are reported annually.1F. tularensis is classified as a Tier 1 Select Agent and has been evaluated as a potential weapon by several countries. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1182667469 ER -