TY  - CHAP
M1  - Book, Section
TI  - Viral Zoonoses—Rabies
A1  - Pieracci •, Emily G.
A1  - Blanton, Jesse D.
A2  - Boulton, Matthew L.
A2  - Wallace, Robert B.
PY  - 2022
T2  - Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e
AB  - Rabies  is  an  acute  progressive  viral  infection  of  the  central  nervous  system  that  has  affected  animals  and  humans  for  millennia.  The  etiological  agents  of  rabies  are  bullet-shaped  RNA  viruses  in  the  genus  Lyssavirus,  family  Rhabdoviridae.  Currently,  16  species  are  recognized  members  of  the  Lyssavirus  genus  (Table  140-1).1  Human  rabies  cases  have  been  attributed  to  six  different  species,  but  rabies  lyssavirus  remains  the  leading  cause  of  rabies  globally.  While  most  warm-blooded  vertebrates  have  been  shown  to  be  susceptible  to  infection  under  experimental  conditions,2,3  mammals  are  the  hosts  responsible  for  maintaining  the  virus  in  nature.  Specifically,  species  in  the  orders  Carnivora  and  Chiroptera  act  as  primary  reservoirs.4  Globally,  the  domestic  dog  is  the  primary  reservoir  and  the  species  most  associated  with  infection  in  humans.5  However,  multiple  wildlife  species  have  also  been  identified  as  reservoirs  of  specific  rabies  virus  variants  and  various  bat  species  as  reservoirs  of  different  Lyssavirus  species.  Human  rabies  cases  are  an  incidental  consequence  of  interaction  with  rabid  animals.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1182666945
ER  -