TY - CHAP M1 - Book, Section TI - Foodborne Trematode Infections A1 - Sapp, Sarah G. H. A1 - Guagliardo, Sarah Anne J. A1 - Bradbury, Richard S. A2 - Boulton, Matthew L. A2 - Wallace, Robert B. PY - 2022 T2 - Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e AB - The trematodes Clonorchis sinensis, Opisthorchis viverrini, and O. felineus are members of the family Opisthorchidae and are important causes of liver disease in people within endemic areas. Notably, and somewhat uniquely among parasitic species, C. sinensis and O. viverrini are classified as group 1 carcinogens due to their association with cholangiocarcinoma and other neoplasms of the biliary system.1 Infections with these “fishborne liver flukes” are widely distributed in countries in the Far East and Southeast Asia, and countries of the former Soviet Union. They present serious public health problems in certain localized areas of China, Korea, Thailand, Laos, Cambodia, Vietnam, and several countries of the former Soviet Union and increasingly into Europe. The most recent estimate of global burden indicates 45 million infections in the endemic Asian and European range; this includes 35 million C. sinensis cases, 10 million O. viverrini cases, and 1.2 million O. felineus cases.2 Up to 680 million people may be at risk for infection.2 Globally, clonorchiasis and opisthorciasis are associated with an estimated 522,863 and 188,346 disability-adjusted life years, which is relatively high among parasitic helminths.3 With increased travel and migration of populations at risk and importation of indigenous uncooked foods contaminated with these parasites, infections have also occurred in nonendemic areas. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/20 UR - accessmedicine.mhmedical.com/content.aspx?aid=1182666311 ER -