TY - CHAP M1 - Book, Section TI - Immunopharmacology A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke A1 - Tuan, Rupa Lalchandani A1 - Vanderah, Todd W. A1 - Trevor, Anthony J. PY - 2021 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 13e AB - The immune system is essential for protection against pathogens. However, when dysregulated, its powerful destructive mechanisms may do more harm than good. Examples include hypersensitivity reactions, autoimmune disorders, and rejection of transplanted tissues. Drugs that suppress immune mechanisms play an important role in treating these conditions. Increasingly, monoclonal antibodies targeting proteins with key roles in immune responses are being developed as immunosuppressive agents. In some situations, drugs that potentiate the immune response provide benefit. A growing number of other conditions now rely on monoclonal antibodies as therapeutics (cancer, cardiovascular conditions, HIV, etc). A small subset of these newer drugs has been withdrawn from the market based on emerging toxicities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180559028 ER -