TY - CHAP M1 - Book, Section TI - Diuretics & Other Drugs That Act on the Kidney A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke A1 - Tuan, Rupa Lalchandani A1 - Vanderah, Todd W. A1 - Trevor, Anthony J. PY - 2021 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 13e AB - Drugs that act on the kidney have important applications in renal, cardiovascular, and endocrine disorders. These disorders mainly involve sodium and water homeostasis. Each segment of the nephron—proximal convoluted tubule (PCT), thick ascending limb (TAL) of the loop of Henle, distal convoluted tubule (DCT), and cortical collecting tubule (CCT)—has a different mechanism for reabsorbing sodium and other ions. The subgroups of the sodium-excreting diuretics are based on these sites and processes in the nephron. Several other drugs mainly alter water excretion. The effects of the diuretic agents are predictable from knowledge of the function of the segment of the nephron in which they act. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/13 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180555824 ER -