TY  - CHAP
M1  - Book, Section
TI  - Microscopic Polyangiitis
A1  - Stone, John H.
A2  - Stone, John H.
PY  - 2021
T2  - Current Diagnosis & Treatment: Rheumatology, 4e
AB  - Microscopic  polyangiitis  (MPA)  is  the  most  common  cause  of  the  pulmonary-renal  syndrome  of  alveolar  hemorrhage  and  glomerulonephritis.Usually  includes  combinations  of  two  or  more  of  the  following:Nonspecific  constitutional  symptoms  including  fatigue,  myalgias,  weight  loss,  and  fevers.Migratory  arthralgias  or  arthritis,  either  pauciarticular  or  polyarticular.Palpable  purpura,  sometimes  with  skin  ulcerations.Sensorimotor  mononeuritis  multiplex.Alveolar  hemorrhage  associated  with  hemoptysis  and  respiratory  compromise.Glomerulonephritis.Antineutrophil  cytoplasmic  antibodies  (ANCAs)  are  often  critical  in  making  the  diagnosis,  but  a  significant  minority  of  patients  are  ANCA-negative.The  majority  of  patients  with  MPA  who  are  ANCA  positive  have  antibodies  directed  against  myeloperoxidase  (MPO-ANCA).ANCA  titers  are  often  elevated  during  disease  flares  but  do  not  have  a  consistent  temporal  relationship  with  disease  activity.  Thus,  caution  must  be  employed  when  making  treatment  decisions  based  on  ANCA  testing.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1180197390
ER  -