TY - CHAP M1 - Book, Section TI - Adult-Onset Still Disease A1 - Guilpain, Philippe A1 - Maria, Alexandre A2 - Stone, John H. PY - 2021 T2 - Current Diagnosis & Treatment: Rheumatology, 4e AB - Quotidian fever, frequently greater than 39°C.Evanescent, salmon-colored macular rash on the trunk and extremities, often coincident with fever spikes, typically in the late afternoon or evening.Other main clinical features are pharyngitis, polyarthralgia, lymphadenopathy, splenomegaly, and serositis.Common laboratory abnormalities include a leukocytosis, elevations of the acute phase reactants (erythrocyte sedimentation rate and C-reactive protein), and dramatic increases in the serum ferritin level.The most striking complication of adult-onset Still disease (AOSD) is reactive hemophagocytic lymphohistiocytosis (RHL), formerly named macrophage activation syndrome. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180196036 ER -