TY - CHAP M1 - Book, Section TI - Endocrine Disorders A1 - Cunningham, F. Gary A1 - Leveno, Kenneth J. A1 - Dashe, Jodi S. A1 - Hoffman, Barbara L. A1 - Spong, Catherine Y. A1 - Casey, Brian M. PY - 2022 T2 - Williams Obstetrics, 26e AB - Endocrinopathies are closely related to pregnancy for several reasons. One example is the gestational proclivity for prodigious hormone secretion, which is perhaps best illustrated by placental lactogen in diabetes. This is the most common endocrinopathy encountered in pregnancy and discussed in Chapter 57. Pregnancy is also interrelated with some endocrinopathies that are at least partially due to autoimmune dysregulation. Clinical manifestations result from complex interplay among genetic, environmental, and endogenous factors that activate the immune system against targeted cells within endocrine organs. In one extraordinary interaction, studies have implicated maternal organ engraftment by fetal cells transferred during pregnancy. These cells later provoke antibody production, tissue destruction, and autoimmune endocrinopathies. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190769503 ER -