TY  - CHAP
M1  - Book, Section
TI  - Hypernatremia
A1  - Mount, David B.
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Hypernatremia  is  defined  as  an  increase  in  the  plasma  Na+  concentration  to  >145  mM.  Considerably  less  common  than  hyponatremia,  hypernatremia  is  nonetheless  associated  with  mortality  rates  of  as  high  as  40–60%,  mostly  due  to  the  severity  of  the  associated  underlying  disease  processes.  Hypernatremia  is  usually  the  result  of  a  combined  water  and  electrolyte  deficit,  with  losses  of  H2O  in  excess  of  Na+.  Less  frequently,  the  ingestion  or  iatrogenic  administration  of  excess  Na+  can  be  causative,  for  example  after  IV  administration  of  excessive  hypertonic  Na+-Cl–  or  Na+-HCO3–(Fig.  49-6).  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1178487157
ER  -