TY - CHAP M1 - Book, Section TI - Treatment of Chronic Hepatitis C A1 - Dienstag, Jules L. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Therapy for chronic hepatitis C has evolved substantially in the 25 years since IFN-α was introduced for this indication in 1991. The therapeutic armamentarium grew to include PEG IFN with ribavirin and, then, in 2011, the introduction of the first protease inhibitors, telaprevir and boceprevir, used in combination with PEG IFN and ribavirin in patients with HCV genotype 1. The field of antiviral therapy for hepatitis C was transformed beginning in 2013, with the approval of the first nucleoside analogue, sofosbuvir. As of 2016, no fewer than six, all-oral, highly effective (>95%), low-resistance, well tolerated, short-duration (usually 12 weeks) combination regimens of DAA drugs are available. The remarkable historical evolution of antiviral therapy for hepatitis C is instructive. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1178426940 ER -