TY - CHAP M1 - Book, Section TI - Inherited Platelet Disorders A1 - Sivapalaratnam, Suthesh A1 - Rao, A. Koneti A1 - Ouwehand, Willem A1 - Freson, Kathleen A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYThis chapter describes the classification, pathophysiology, clinical evaluation, and management of quantitative and qualitative inherited platelet disorders. Whereas some platelet disorders only result in bleeding, others are part of a broader clinical syndrome. Even with signs of bleeding, there is a large variability among patients. Bleeding is principally evident by excessive hemorrhage at mucocutaneous sites, ecchymoses, petechiae, epistaxis, gingival hemorrhage, and menorrhagia. The hereditary platelet disorders can be classified according to the underlying genetic mutation and the role the corresponding protein has in megakaryocyte and platelet production (Figs. 119–1 and 119–2). Furthermore, recommendations on how and when to use genomic analyses and deep sequencing in the diagnosis of possibly novel pathways that result in inherited platelet disorders are provided.1,2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1178754589 ER -