TY - CHAP M1 - Book, Section TI - Anemia Associated with Marrow Infiltration A1 - V.B. Reddy, Vishnu A1 - Morlote, Diana A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYMyelophthisic anemia is caused by marrow infiltration, typically by metastatic cancer but also by any nonhematopoietic conditions such as granulomatous inflammation or fibrosis. It can present with an overt leukoerythroblastic picture or with only a few teardrop-shaped red cells on a blood film. These changes may represent an early spread of the tumor (or other nonhematopoietic entities) to the marrow or may indicate massive replacement of the marrow space. The diagnosis can be made by standard marrow biopsy. Radioisotope scanning, positron emission tomography/computerized tomography, and magnetic resonance imaging, although not very sensitive, can be helpful in locating the biopsy site and can also help in estimating the percentage of involvement of the marrow space. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1178740845 ER -