TY - CHAP M1 - Book, Section TI - Antifungal Agents A1 - Lampiris, Harry W. A1 - Maddix, Daniel S. A2 - Katzung, Bertram G. A2 - Vanderah, Todd W. PY - 2021 T2 - Basic & Clinical Pharmacology, 15e AB - CASE STUDYThe patient is a 37-year-old African-American man who lives in San Jose, California*. He was recently incarcerated near Bakersfield, California and returned to Oakland about 3 months ago. He is currently experiencing 1 month of severe headache and double vision. He has a temperature of 38.6°C (101.5°F), and the physical exam reveals nuchal rigidity and right-sided sixth cranial nerve palsy. MRI of his brain is normal, and lumbar puncture reveals 330 WBC with 20% eosinophils, protein 75, and glucose 20. HIV test is negative, TB skin test is negative, CSF cryptococcal antigen is negative, and CSF gram stain is negative. Patient receives empiric therapy for bacterial meningitis with vancomycin and ceftriaxone, and is unimproved after 72 hours of treatment. After 3 days a white mold is identified growing from his CSF culture. What medical therapy would be most appropriate now? SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1176976855 ER -