TY - CHAP M1 - Book, Section TI - Methemoglobinemia A1 - Williams, Saralyn R. A1 - Thurman, R. Jason A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason PY - 2021 T2 - The Atlas of Emergency Medicine, 5e AB - Methemoglobin occurs when the iron in deoxyhemoglobin loses an electron, resulting in a ferric (Fe3+) ion instead of the usual ferrous (Fe2+) state. Ferric iron can no longer bind to oxygen, thereby reducing the oxygen-carrying capacity of hemoglobin. The presence of methemoglobin also shifts the oxygen hemoglobin dissociation curve to the left, resulting in decreased release of oxygen to tissues. Infants are more susceptible to the development of methemoglobinemia. Illnesses in infants such as diarrhea, dehydration, and acidosis may induce methemoglobin due to oxidant stress. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181056869 ER -