TY - CHAP M1 - Book, Section TI - Cholinergic Toxidrome A1 - Williams, Saralyn R. A1 - Thurman, R. Jason A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason PY - 2021 T2 - The Atlas of Emergency Medicine, 5e AB - Acetylcholine (Ach) is a neurotransmitter of both the central and peripheral nervous system. It is the neurotransmitter for both muscarinic and nicotinic receptors. Inhibition of acetylcholinesterase increases Ach in the synapse. This results in the clinical syndrome of both muscarinic and nicotinic effects. One mnemonic for the muscarinic effects is DUMBBEL(L)S: diarrhea, urination, miosis, bronchorrhea, bradycardia, emesis, lacrimation, and salivation. Nicotinic effects include the fasciculations, paralysis, and occasional sympathomimetic effects of mydriasis and tachycardia. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181056708 ER -