TY - CHAP M1 - Book, Section TI - Slow Viruses & Prions A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian PY - 2020 T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e AB - “Slow” infectious diseases are caused by a heterogeneous group of agents containing both conventional viruses and unconventional agents that are not viruses (e.g., prions). Prions are protein-containing particles with no detectable nucleic acid that are highly resistant to inactivation by heat, formaldehyde, and ultraviolet light at doses that will inactivate viruses. Note that prions are resistant to the temperatures usually employed in cooking, a fact that may be important in their suspected ability to be transmitted by food (see variant Creutzfeldt-Jakob disease [vCJD] later). Prions are, however, inactivated by protein- and lipid-disrupting agents such as phenol, ether, NaOH, and hypochlorite (see Chapter 28). SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1175830224 ER -