TY - CHAP M1 - Book, Section TI - Major Histocompatibility Complex & Transplantation A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian PY - 2020 T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e AB - The success of tissue and organ transplants depends on the donor’s and recipient’s major histocompatibility complex (MHC) proteins, which present antigens to T cells. The MHC proteins are alloantigens (i.e., they differ among members of the same species). In humans, these proteins are encoded by the human leukocyte antigen (HLA) genes, clustered on chromosome 6. (Note that we will use MHC and HLA interchangeably.) Three of these genes (HLA-A, HLA-B, and HLA-C) code for the class I MHC proteins. Several HLA-D loci determine the class II MHC proteins (i.e., DP, DQ, and DR) (Figure 62–1). The features of class I and class II MHC proteins are compared in Table 62–1. If the HLA proteins on the donor’s cells differ from those on the recipient’s cells, then an immune response occurs in the recipient. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1175827037 ER -