TY - CHAP M1 - Book, Section TI - Gout & The Kidney A1 - Dirkx, Tonja C. A1 - Woodell, Tyler B. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. PY - 2021 T2 - Current Medical Diagnosis & Treatment 2021 AB - The kidney is the primary organ for excretion of uric acid. Patients with proximal tubular dysfunction have decreased excretion of uric acid and are more prone to gouty arthritis attacks. Depending on the pH and uric acid concentration, deposition can occur in the tubules, the interstitium, or the urinary tract. The more alkaline pH of the interstitium causes urate salt deposition, whereas the acidic environment of the tubules and urinary tract causes uric acid crystal deposition at high concentrations. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/01/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1177463038 ER -