TY - CHAP M1 - Book, Section TI - VASODILATORS A1 - Fay, Jeffrey A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - A variety of vasodilators and alpha receptor blockers are used in clinical medicine. Nonselective alpha-adrenergic blocking agents (eg, phenoxybenzamine, phentolamine, and tolazoline) have been used in clinical practice since the 1940s. The first selective alpha1 blocker, prazosin, was introduced in the early 1970s; doxazosin, indoramin, terazosin, trimazosin, urapidil, and tamsulosin are newer alpha1-selective agents. Minoxidil, hydralazine, and diazoxide are directly acting peripheral vasodilators. Fenoldopam is a dopamine-1 receptor agonist approved for short-term management of severe hypertension. Nesiritide is a recombinant peptide that is used for the intravenous treatment of acutely decompensated congestive heart failure. Sildenafil, tadalafil, vardenafil, and avenafil are used in the treatment of male erectile dysfunction. Nitroprusside and nitrates are discussed elsewhere. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174607257 ER -