TY - CHAP M1 - Book, Section TI - Multiple Sclerosis A1 - Jameson, J. Larry A1 - Fauci, Anthony S. A1 - Kasper, Dennis L. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Loscalzo, Joseph PY - 2020 T2 - Harrison's Manual of Medicine, 20e AB - Characterized by inflammation, selective destruction of CNS myelin, and neurodegeneration; peripheral nervous system is spared. Pathologically, the multifocal scarred lesions of multiple sclerosis (MS) are termed plaques. Etiology is autoimmune, with susceptibility determined by genetic and environmental factors. MS affects >900,000 in the United States and 3 million worldwide; onset is often in early to middle adulthood, and women are affected three times as often as men. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/25 UR - accessmedicine.mhmedical.com/content.aspx?aid=1167069213 ER -