TY  - CHAP
M1  - Book, Section
TI  - Cancer of Unknown Primary Site
A1  - Jameson, J. Larry
A1  - Fauci, Anthony S.
A1  - Kasper, Dennis L.
A1  - Hauser, Stephen L.
A1  - Longo, Dan L.
A1  - Loscalzo, Joseph
PY  - 2020
T2  - Harrison's Manual of Medicine, 20e
AB  - Cancer  of  unknown  primary  site  (CUPS)  is  defined  as  follows:  biopsy-proven  malignancy;  primary  site  unapparent  after  history,  physical  examination,  chest  x-ray,  abdominal  and  pelvic  CT,  complete  blood  count,  chemistry  survey,  mammography  (women),  β-human  chorionic  gonadotropin  (hCG)  levels  (men),  α-fetoprotein  (AFP)  levels  (men),  and  prostate-specific  antigen  (PSA)  levels  (men);  and  histologic  evaluation  not  consistent  with  a  primary  tumor  at  the  biopsy  site.  About  90%  of  CUPS  tumors  are  adenocarcinomas  (60%  well  or  moderately–well  differentiated;  30%  poorly  differentiated),  5%  squamous  cell,  2%  neuroendocrine,  and  3%  undifferentiated  malignancy.  CUPS  incidence  is  declining,  probably  because  of  better  pathology  diagnostic  criteria;  it  accounts  for  about  3%  of  all  cancers  today,  down  from  10–15%  15  years  ago.  Most  pts  are  age  >60.  The  tumors  are  often  aneuploid.  Cell  lines  derived  from  such  tumors  frequently  have  abnormalities  in  chromosome  1.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1167064433
ER  -