TY  - CHAP
M1  - Book, Section
TI  - Fever, Hyperthermia, and Rash
A1  - Jameson, J. Larry
A1  - Fauci, Anthony S.
A1  - Kasper, Dennis L.
A1  - Hauser, Stephen L.
A1  - Longo, Dan L.
A1  - Loscalzo, Joseph
PY  - 2020
T2  - Harrison's Manual of Medicine, 20e
AB  - Temperature:  The  hypothalamic  thermoregulatory  center  balances  excess  heat  production  from  metabolic  activity  in  muscle  and  liver  with  heat  dissipation  from  the  skin  and  lungs  to  maintain  a  normal  body  temperature  of  36.8°  ±  0.4°C  (98.2°  ±  0.7°F),  with  diurnal  variation  (lower  in  A.M.,  higher  in  P.M.)Fever:  An  elevation  of  body  temperature  (>37.2°C/98.9°F  in  the  morning  and  >37.7°C/99.9°F  in  the  evening)  in  conjunction  with  an  increase  in  the  hypothalamic  set  pointFever  of  unknown  origin(FUO):  Temperatures  >38.3°C  (>101°F)  on  two  or  more  occasions  and  an  illness  duration  of  ≥3  weeks,  with  no  known  immunocompromised  state  and  unrevealing  laboratory  and  radiologic  investigations  into  the  causeHyperpyrexia:  Temperatures  >41.5°C  (>106.7°F)  that  can  occur  with  severe  infections  but  more  commonly  occur  with  CNS  hemorrhagesHyperthermia:  An  uncontrolled  increase  in  body  temperature  that  exceeds  the  body’s  ability  to  lose  heat  without  a  change  in  the  hypothalamic  set  point.  Hyperthermia  does  not  involve  pyrogenic  molecules.Pyrogen:  Any  fever-causing  substance,  including  exogenous  pyrogens  (e.g.,  microbial  toxins,  lipopolysaccharide,  superantigens)  and  pyrogenic  cytokines  (e.g.,  IL-1,  IL-6,  TNF)  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1167062918
ER  -