TY - CHAP M1 - Book, Section TI - Antimicrobials A1 - Connors, Nicholas J. A1 - Carter, Wallace A. A2 - Tintinalli, Judith E. A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Stapczynski, J. Stephan A2 - Cline, David M. A2 - Thomas, Stephen H. PY - 2020 T2 - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e AB - Adverse effects associated with antimicrobials occur primarily in three circumstances: side effects with therapeutic dosing, subacute to chronic effects from sustained therapeutic use, and acute toxicity resulting from excessive dosing. Side effects can be immunologic (allergic) or nonimmunologic (pharmacologic or idiosyncratic) in nature. Antibiotics cause more reported allergic reactions than other drugs, possibly due to their high frequency of use often in a repeated and interrupted fashion. Sometimes a diluent or other chemical constituent in the formulation of a drug causes the adverse effect. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174228317 ER -