TY - CHAP M1 - Book, Section TI - Barbiturates A1 - Gresham, Chip A1 - LoVecchio, Frank A2 - Tintinalli, Judith E. A2 - Ma, O. John A2 - Yealy, Donald M. A2 - Meckler, Garth D. A2 - Stapczynski, J. Stephan A2 - Cline, David M. A2 - Thomas, Stephen H. PY - 2020 T2 - Tintinalli's Emergency Medicine: A Comprehensive Study Guide, 9e AB - Barbiturates are still the most common class of antiepileptic drugs used in developing countries, but their use is declining due to the introduction of safer, less toxic sedative-hypnotics (e.g., benzodiazepines) and second-generation anticonvulsants.1 Status epilepticus,2 severe ethanol and sedative withdrawal syndromes,3-5 and toxicologic seizures6 are typically managed with benzodiazepines, but barbiturates have a useful role as second-line agents. They are still used in combination drugs (e.g., butalbital) and alone (e.g., secobarbital) for the treatment of tension and migraine headaches7-9 and for refractory intracranial hypertension from focal and diffuse brain injury.10 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1166599879 ER -