TY - CHAP M1 - Book, Section TI - Sickle Cell Disease A1 - Al-Kindi, Salam A1 - McKinley-Grant, Lynn A1 - Sode, Titilola A2 - Kelly, A. Paul A2 - Taylor, Susan C. A2 - Lim, Henry W. A2 - Serrano, Ana Maria Anido PY - 2016 T2 - Taylor and Kelly's Dermatology for Skin of Color, 2e AB - KEY POINTSSickle cell disease (SCD) is prevalent in sub-Saharan Africa, the Middle East, India, and most tropical climates where malaria is present.The SCD group of disorders can include all genotypes (eg, HbSS, HbSC, and HbSβ-thalassemia), unlike sickle cell anemia which occurs only with the HbSS genotype. SCD is characterized by recurrent vaso-occlusive crises, anemia, and a predisposition for infections.Patients with SCD commonly present with jaundice and/or pallor.A physical examination of the patient should include nonpathognomonic skin findings, stroke, pectus excavatum, body habitus, and an enlarged spleen, as well as the cutaneous symptoms of renal failure (see Chapter 73, Renal Disease).Leg ulcers are a common cutaneous manifestation of SCD.In children, hand-foot syndrome (dactylitis) is typically the first cutaneous marker of this condition. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161549260 ER -