TY - CHAP M1 - Book, Section TI - Dapsone A1 - Goh, Chee Leok A1 - Pan, Jiun Yit A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEDapsone (4,4′-diaminodiphenylsulfone) is a sulfonamide with unique pharmacologic action.It is used as an antiinfective in particular against Hensen disease and selected fungal infections such as actinomycetoma and rhinosporidiosis. It is also used for the treatment of malaria and as a prophylaxis for toxoplasmosis.It is also an antiinflammatory agents and is effective against dermatitis herpetiformis, erythema elevatum diutinum, linear immunoglobulin A dermatosis and chronic bullous disease of childhood, and bullous eruption of systemic lupus erythematosus.It has antineutrophilic effect and used against collagen vascular and autoimmune diseases and recently topically for acne.It is often used as corticosteroid-sparing agent.Significant side effects to watch for include hemolysis and methemoglobinemia, which are frequently observed in patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Dapsone should only be given with great caution and in very special circumstances to patients with G6PD deficiency when the benefits outweigh the risks when constant hemoglobin and monitoring of reticulocyte counts is essential.Other serious side effects include drug hypersensitivity syndrome (sulphone syndrome), Stevens-Johnson syndrome, and agranulocytosis.Dapsone is classified as C Pregnancy Category (ie, risk not ruled out). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161343635 ER -