TY - CHAP M1 - Book, Section TI - Genetic Disorders Affecting Dermal Connective Tissue A1 - Dyer, Jonathan A. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - Inherited connective tissue disorders are clinically and genetically diverse conditions affecting the skin, joints, and a variety of extracutaneous tissues, including the cardiovascular (CV) system. The nature and severity of the skin phenotype is dependent on the type of mutation as well as the role of the affected protein on dermal structure and function (see Chaps. 15 and 18). The diagnosis of many inherited connective tissue disorders is clinical, although Clinical Laboratory Improvement Amendments (1988) (CLIA)-approved genetic testing is increasingly available. A listing of research laboratories that might offer testing can be found at http://www.genetests.org. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161323641 ER -