TY  - CHAP
M1  - Book, Section
TI  - HIV Neurology
A1  - Saylor, Deanna
A1  - Sacktor, Ned
A1  - Rumbaugh, Jeffrey
A1  - Sevigny, Jeffrey
A1  - Estanislao, Lydia B.
A2  - Brust, John C.M.
PY  - 2019
T2  - CURRENT Diagnosis & Treatment: Neurology, 3e
AB  - HIV  is  a  retrovirus  belonging  to  the  subfamily  Lentivirus  (slow  virus),  so-called  because  of  the  long  latency  period  between  primary  infection  and  the  CD4+  T-cell  depletion  that  characterizes  AIDS.  During  this  latency  period,  the  immune  system  becomes  dysregulated  and  a  chronic  proinflammatory  state  develops,  manifesting  with  hypergammaglobulinemia  and  an  increased  secretion  of  several  cytokines.  Many  neurologic  complications,  particularly  those  occurring  before  the  onset  of  AIDS,  are  attributable  to  immune-mediated  processes.  Without  virologic  control,  eventually  all  components  of  the  immune  system  (particularly  the  cellular  response)  become  deficient,  enabling  opportunistic  infections  and  malignancies  to  develop.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1159972808
ER  -