TY - CHAP M1 - Book, Section TI - Myopathies A1 - van de Rijn, Marc A1 - Tolchin, Dorothy Weiss A1 - Paganoni, Sabrina A2 - Mitra, Raj PY - 2019 T2 - Principles of Rehabilitation Medicine AB - Myopathies are diseases characterized by primary muscle pathology.1 They can be inherited, acquired, associated with other diseases, or result from toxic exposures. The primary clinical manifestation of a myopathy is weakness, and accompanying symptoms can include (but are not limited to) wasting, cramps, spasms, myoclonus, contractures, and fatigue. Endurance and functional capacity are limited to varying degrees in different classes of myopathies. The pattern of weakness, constellation of associated symptoms, nature of progression, and other organ involvement together can point to a specific diagnosis (see Fig. 75–1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/16 UR - accessmedicine.mhmedical.com/content.aspx?aid=1159834997 ER -