TY - CHAP M1 - Book, Section TI - Neuromuscular Disease: Motor Neuron Disorders A1 - Williams, Lisa M. A1 - Fini, Habib Mofakham A1 - Joyce, Nanette C. A2 - Mitra, Raj PY - 2019 T2 - Principles of Rehabilitation Medicine AB - Motor neuron diseases (mnds) are a heterogeneous group of neurologic conditions characterized by corticospinal tract and anterior horn cell degeneration of the brain and spinal cord1 (Fig. 71–1). While the etiology of MNDs is broad and not clearly elucidated, there is evidence supporting multifactorial processes that can be inherited genetically or acquired sporadically through environmental exposures such as toxins, infections, and autoimmune or other causes.2–8 The common pathology is the destruction of motor neurons and encompasses disorders with selective loss of lower motor neurons (LMNs), upper motor neurons (UMNs), or a combination of both.2 This results in muscle weakness and disability with loss of normal limb, speech, swallow, and respiratory functions. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/15 UR - accessmedicine.mhmedical.com/content.aspx?aid=1159834639 ER -