TY - CHAP M1 - Book, Section TI - Developmental Diseases of the Nervous System A1 - Ropper, Allan H. A1 - Samuels, Martin A. A1 - Klein, Joshua P. A1 - Prasad, Sashank PY - 2019 T2 - Adams and Victor's Principles of Neurology, 11e AB - This broad heading subsumes a large number of both genetically driven developmental malformations and diseases acquired during intrauterine or early neonatal periods of life. They number in the hundreds according to the tabulation of Dyken and Krawiecki although many, if not most, are rare. Taxonomically, they make up two categories. The first includes specific gene defects, either mutations, deletions, or duplications of parts of genes (copy number variation), or single nucleotide polymorphisms that give rise to developmental aberrations or delays. The second category comprises a variety of environmental and infectious agents acting at different times on the immature nervous system during embryonal, fetal, and perinatal periods of life. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1162597479 ER -