TY - CHAP M1 - Book, Section TI - Heavy Metals A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke A1 - Trevor, Anthony J. PY - 2019 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 12e AB - The heavy metals discussed in this chapter—lead, arsenic, mercury, and iron—frequently cause toxicity in humans. The toxicity profiles of metals differ, but most of their effects appear to result from interaction with essential cations, sulfhydryl groups of enzymes, and regulatory proteins. Chelators are organic compounds with 2 or more electronegative groups that form stable bonds with cationic metal atoms. These stable complexes lack the toxicity of the free metals and often are excreted readily. Chelators, which function as chemical antagonists, are used as antidotes in the treatment of heavy metal poisoning. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156531563 ER -