TY - CHAP M1 - Book, Section TI - Local Anesthetics A1 - Katzung, Bertram G. A1 - Kruidering-Hall, Marieke A1 - Trevor, Anthony J. PY - 2019 T2 - Katzung & Trevor's Pharmacology: Examination & Board Review, 12e AB - Local anesthesia results when sensory transmission from a local area of the body to the CNS is blocked. The local anesthetics constitute a group of chemically similar agents (esters and amides) that block the sodium channels of excitable membranes. Because these drugs can be administered by injection in the target area, or by topical application in some cases, the anesthetic effect can be restricted to a localized area (eg, the cornea or an arm). When given intravenously, local anesthetics have effects on other tissues, eg, heart. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156528885 ER -