TY  - CHAP
M1  - Book, Section
TI  - Peptic Ulcer Disease and Related Disorders
A1  - Valle, John Del
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - A  peptic  ulcer  is  defined  as  disruption  of  the  mucosal  integrity  of  the  stomach  and/or  duodenum  leading  to  a  local  defect  or  excavation  due  to  active  inflammation.  Although  burning  epigastric  pain  exacerbated  by  fasting  and  improved  with  meals  is  a  symptom  complex  associated  with  peptic  ulcer  disease  (PUD),  it  is  now  clear  that  >90%  patients  with  this  symptom  complex  (dyspepsia)  do  not  have  ulcers  and  that  the  majority  of  patients  with  peptic  ulcers  may  be  asymptomatic.  Ulcers  occur  within  the  stomach  and/or  duodenum  and  are  often  chronic  in  nature.  Acid  peptic  disorders  are  very  common  in  the  United  States,  with  4  million  individuals  (new  cases  and  recurrences)  affected  per  year.  Lifetime  prevalence  of  PUD  in  the  United  States  is  ~12%  in  men  and  10%  in  women.  PUD  significantly  affects  quality  of  life  by  impairing  overall  patient  well-being  and  contributing  substantially  to  work  absenteeism.  Moreover,  an  estimated  15,000  deaths  per  year  occur  as  a  consequence  of  complicated  PUD.  The  financial  impact  of  these  common  disorders  has  been  substantial,  with  an  estimated  burden  on  direct  and  indirect  health  care  costs  of  ~$6  billion  per  year  in  the  United  States,  with  $3  billion  spent  on  hospitalizations,  $2  billion  on  physician  office  visits,  and  $1  billion  in  decreased  productivity  and  days  lost  from  work.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1160015302
ER  -