TY - CHAP M1 - Book, Section TI - Cryptococcosis A1 - Casadevall, Arturo A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Cryptococcus, a genus of yeast-like fungi, is the etiologic agent of cryptococcosis. Until recently, cryptococcal strains were separated into two species, Cryptococcus neoformans and Cryptococcus gattii, both of which can cause cryptococcosis in humans. The two varieties of C. neoformans—grubii and neoformans—correlate with serotypes A and D, respectively. C. gattii, although not divided into varieties, also is antigenically diverse, encompassing serotypes B and C. However, genome sequencing studies have now revealed tremendous diversity among isolates previously assigned to each species, suggesting that some may be reclassified as new species. Most clinical microbiology laboratories do not routinely distinguish between C. neoformans and C. gattii or among varieties, but rather identify and report all isolates simply as C. neoformans. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1155971238 ER -