TY - CHAP M1 - Book, Section TI - Ebolavirus and Marburgvirus Infections A1 - Kuhn, Jens H. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Several viruses of the family Filoviridae cause severe and frequently fatal infections in humans. Introduction of filoviruses into human populations is an extremely rare event that most likely occurs by direct or indirect contact with healthy filovirus hosts or by contact with infected, sick, or deceased mammals. Filoviruses are highly infectious but not especially contagious. Human-to-human transmission takes place through direct person-to-person (usually skin-to-skin) contact or exposure to infected bodily fluids and tissues; no evidence of such transmission by aerosol or respiratory droplets in natural outbreak settings is available. Infections progress rapidly from influenza-like to gastrointestinal manifestations and coagulopathy, typically culminating in multiple-organ dysfunction syndrome and shock. The occurrence of primary subclinical infections is controversial, but a small percentage of survivors may be subclinically and persistently infected. Treatment of filovirus infections is entirely supportive in nature because no specific efficacious antiviral agents or vaccines are yet licensed. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1155971093 ER -