TY  - CHAP
M1  - Book, Section
TI  - Cancer Genetics
A1  - Bunz, Fred
A1  - Vogelstein, Bert
A2  - Jameson, J. Larry
A2  - Fauci, Anthony S.
A2  - Kasper, Dennis L.
A2  - Hauser, Stephen L.
A2  - Longo, Dan L.
A2  - Loscalzo, Joseph
PY  - 2018
T2  - Harrison's Principles of Internal Medicine, 20e
AB  - Cancer  arises  through  a  series  of  somatic  alterations  in  DNA  that  result  in  unrestrained  cellular  proliferation.  Most  of  these  alterations  involve  subtle  sequence  changes  in  DNA  (i.e.,  mutations).  The  somatic  mutations  may  originate  as  a  consequence  of  random  replication  errors  or  exposure  to  carcinogens  (e.g.,  radiation)  and  can  be  exacerbated  by  faulty  DNA  repair  processes.  While  most  cancers  arise  sporadically,  clustering  of  cancers  occurs  in  families  that  carry  a  germline  mutation  in  a  cancer  gene.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1156505185
ER  -