TY - CHAP M1 - Book, Section TI - Intracellular Traffic & Sorting of Proteins A1 - Botham, Kathleen M. A1 - Murray, Robert K. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Indicate that many proteins are targeted by signal sequences to their correct destinations and that the Golgi apparatus plays an important role in sorting proteins.Recognize that specialized signals are involved in sorting proteins to mitochondria, the nucleus, and to peroxisomes.Explain that N-terminal signal peptides play a key role in directing newly synthesized proteins into the lumen of the endoplasmic reticulum (ER).Explain how chaperones prevent faulty folding of other proteins, how misfolded proteins are disposed of, and how the ER acts as a quality control compartment.Explain the role of ubiquitin as a key molecule in protein degradation.Recognize the important role of transport vesicles in intracellular transport.Indicate that many diseases result from mutations in genes encoding proteins involved in intracellular transport. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1160192994 ER -