TY - CHAP M1 - Book, Section TI - RNA Synthesis, Processing, & Modification A1 - Weil, P. Anthony A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Describe the molecules involved and the mechanism of RNA synthesis.Explain how eukaryotic DNA-dependent RNA polymerases, in collaboration with an array of specific accessory factors, can differentially transcribe genomic DNA to produce specific messenger RNA (mRNA) precursor molecules.Describe the structure of eukaryotic mRNA precursors, which are highly modified internally and at both termini.Appreciate the fact that the majority of mammalian mRNA-encoding genes are interrupted by multiple nonprotein coding sequences termed introns, which are interspersed between protein coding regions termed exons.Explain that since intron RNA does not encode protein, the intronic RNA must be specifically and accurately removed in order to generate functional mRNAs from the mRNA precursor molecules in a series of precise molecular events termed RNA splicing.Explain the steps and molecules that catalyze mRNA splicing, a process that converts the end-modified precursor molecules into mRNAs that are functional for translation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/01 UR - accessmedicine.mhmedical.com/content.aspx?aid=1160190931 ER -