TY - CHAP M1 - Book, Section TI - Porphyrins & Bile Pigments A1 - Rodwell, Victor W. A1 - Murray, Robert K. A2 - Rodwell, Victor W. A2 - Bender, David A. A2 - Botham, Kathleen M. A2 - Kennelly, Peter J. A2 - Weil, P. Anthony PY - 2018 T2 - Harper's Illustrated Biochemistry, 31e AB - OBJECTIVESAfter studying this chapter, you should be able to:Write the structural formulas of the two amphibolic intermediates whose condensation initiates heme biosynthesis.Identify the enzyme that catalyzes the key regulated enzyme of hepatic heme biosynthesis.Explain why, although porphyrinogens and porphyrins both are tetrapyrroles, porphyrins are colored whereas porphyrinogens are colorless.Specify the intracellular locations of the enzymes and metabolites of heme biosynthesis.Outline the causes and clinical presentations of various porphyrias.Identify the roles of heme oxygenase and of UDP-glucosyl transferase in heme catabolism.Define jaundice, name some of its causes, and suggest how to determine its biochemical basis.Specify the biochemical basis of the clinical laboratory terms “direct bilirubin” and “indirect bilirubin.” SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1160190444 ER -