TY - CHAP M1 - Book, Section TI - Membranoproliferative Glomerulonephritis A1 - Trachtman, Howard A2 - Lerma, Edgar V. A2 - Rosner, Mitchell H. A2 - Perazella, Mark A. PY - 2017 T2 - CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e AB - ESSENTIALS OF DIAGNOSISCharacterized by persistent hypocomplementemia.Disease is most often primary or idiopathic.Disease can occur secondary to immunoglobulin-mediated activation of the complement cascade or acquired or genetic abnormalities in the alternate pathway of complement.Fifty percent of patients progress to end-stage renal disease over 10–15 years.Prednisone is effective in pediatric patients but there is no proven treatment in adults.Disease recurs post-transplantation in approximately 25% of patients. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1149114080 ER -