TY - CHAP M1 - Book, Section TI - Mutation A1 - Schaefer, G. Bradley A1 - Thompson, Jr., James N. PY - 2017 T2 - Medical Genetics: An Integrated Approach AB - In earlier chapters, we saw how genes produce the enzymes that control specific biochemical reactions. Normal development depends on these information coding and regulatory systems working properly. But DNA replication is not perfect. Biochemical mistakes happen. Most replication errors are corrected by repair enzymes, but those that are missed become new mutations. In the broadest sense, then, a mutation is a heritable genetic change passed from one cell to another. For that reason, the biochemical correction mechanisms that work in parallel with replication are important for biological continuity. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1147722698 ER -