TY - CHAP M1 - Book, Section TI - Treatment of Pulmonary Arterial Hypertension A1 - Fraidenburg, Dustin R. A1 - Desai, Ankit A. A1 - Yuan, Jason X.-J. A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - AbbreviationsATPase: adenosine triphosphataseBMPR2: bone morphogenetic protein receptor type 2[Ca2+]cyt: cytosolic free Ca2+ concentrationCCB: calcium channel blockerCOPD: chronic obstructive pulmonary diseaseCTEPH: chronic thromboembolic pulmonary hypertensionCYP: cytochrome P450DAG: diacylglycerolEC: endothelial cellECE: endothelin-converting enzymeEGF: epidermal growth factorERA: endothelin receptor antagonistET: endothelin-1FDA: Food and Drug AdministrationHCN: hyperpolarization-activated cyclic nucleotide–gatedHIV: human immunodeficiency virusHPAP: heritable pulmonary arterial hypertensionHPV: hypoxic pulmonary vasoconstriction5HT: serotoninIP3: inositol triphosphateIPAH: idiopathic pulmonary arterial hypertensionIPR: prostacyclin receptorLV: left ventriclemGC: membrane guanylate cyclase6MWT: six-minute walk testingNO: nitric oxideNO2: nitric dioxideNYHA: New York Heart AssociationPA: pulmonary arteryPAEC: pulmonary arterial endothelial cellPAH: pulmonary arterial hypertensionPao2: partial pressure of arterial O2PAOP: pulmonary artery occlusion pressurePAP: pulmonary arterial pressurePASMC: pulmonary artery smooth muscle cellPDE: phosphodiesterasePDGF: platelet-derived growth factorPGI2: prostacyclin, prostaglandin I2PH: pulmonary hypertensionPIP2: phosphatidylinositol 4,5-biphosphatePKA: protein kinase APKG: protein kinase GPLC: phospholipase CPVR: pulmonary vascular resistanceRAP: right atrial pressureROC: receptor-operated Ca2+ channelRV: right ventricleRVF: right ventricular failureRVH: right ventricular hypertrophyRVSP: right ventricular systolic pressuresGC: soluble guanylate cyclaseSR: sarcoplasmic reticulumSVR: systemic vascular resistanceTKR: tyrosine kinase receptorTxA2: thromboxane A2VDCC: voltage-dependent Ca2+ channelVEGF: vascular endothelial growth factorsVIP: vasoactive intestinal peptideVSM: vascular smooth muscle SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1162538907 ER -