TY - CHAP M1 - Book, Section TI - Drug Metabolism A1 - Gonzalez, Frank J. A1 - Coughtrie, Michael A1 - Tukey, Robert H. A2 - Brunton, Laurence L. A2 - Hilal-Dandan, Randa A2 - Knollmann, Björn C. PY - 2017 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e AB - AbbreviationsADR: adverse drug reactionAUC: area under the plasma concentration–time curveAZA: azathioprineCAR: constitutive androstane receptorCES2: carboxylesterase 2COMT: catechol-O-methyltransferaseCPT-11: irinotecanCYP: cytochrome P450DPYD: dihydropyrimidine dehydrogenaseEH: epoxide hydrolaseFMO: flavin-containing monooxygenaseGI: gastrointestinalGSH and GSSG: reduced and oxidized glutathioneGST: glutathione-S-transferaseHGPRT: hypoxanthine guanine phosphoribosyl transferaseHIF: hypoxia-inducible factorHIV: human immunodeficiency virusHNMT: histamine N-methyltransferaseHPPH: 5-(-4-hydroxyphenyl)-5-phenylhydantoinINH: isonicotinic acid hydrazide (isoniazid)MAO: monoamine oxidaseMAPK: mitogen-activated protein kinasemEH: microsomal epoxide hydrolase6-MP: 6-mercaptopurineMRP: multidrug resistance proteinMT: methyltransferaseNADPH: nicotinamide adenine dinucleotide phosphateNAPQI:N-acetyl-p-benzoquinone imineNAT:N-acetyltransferaseNNMT: nicotinamide N-methyltransferasePAPS: 3′-phosphoadenosine-5′-phosphosulfatePer: PeriodPgp: P-glycoproteinPNMT: phenylethanolamine N-methyltransferasePOMT: phenol-O-methyltransferasePPAR: peroxisome proliferator–activated receptorPXR: pregnane X receptorRXR: retinoid X receptorSAM:S-adenosyl-methioninesEH: soluble epoxide hydrolaseSULT: sulfotransferaseTBP: TATA box–binding protein6-TGN: 6-thioguanine nucleotideTMA: trimethylamineTPMT: thiopurine methyltransferaseTPT: thiol methyltransferaseUDP-GA: uridine diphosphate–glucuronic acidUGT: uridine diphosphate–glucuronosyltransferase SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1162533383 ER -