TY - CHAP M1 - Book, Section TI - Folate Antagonists A1 - Stringer, Janet L. PY - 2017 T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 5e AB - To understand the mechanism of action of this class of drugs, we need to first review the synthesis of folic acid (Figure 28–1). Bacteria cannot absorb folic acid, but must make it from PABA (para-aminobenzoic acid), pteridine, and glutamate. For humans, folic acid is a vitamin. We cannot synthesize it. This makes this metabolic pathway a nice, selective target for antimicrobial agents. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1142821517 ER -