TY - CHAP M1 - Book, Section TI - Antiplatelet Therapy A1 - Michael, Tesfaldet T. A1 - Gupta, Saurabh A2 - Crawford, Michael H. PY - 2017 T2 - CURRENT Diagnosis & Treatment: Cardiology, 5e AB - Atherosclerosis is a leading cause of cardiovascular disease. Atherosclerotic plaques can acutely rupture, exposing a necrotic core that sets off the coagulation cascade, ultimately culminating in vascular occlusion. Activation of platelets is the initial event in this cascade and, depending on the vascular bed involved, can cause acute coronary syndromes, ischemic stroke, mesenteric ischemia, or acute limb ischemia. Antiplatelet therapy forms the core of treatment for both acute and chronic atherosclerotic disease. In this chapter, we will discuss antiplatelet therapy for treatment of cardiovascular disease. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1139743344 ER -