TY - CHAP M1 - Book, Section TI - Abnormalities in Red Blood Cells A1 - Verhovsek, Madeleine A1 - McFarlane, Andrew A2 - McKean, Sylvia C. A2 - Ross, John J. A2 - Dressler, Daniel D. A2 - Scheurer, Danielle B. PY - 2017 T2 - Principles and Practice of Hospital Medicine, 2e AB - Key Clinical QuestionsAnemia How does peripheral blood smear aid in the diagnosis of anemia? How do I interpret iron studies? What are the best tests to diagnose hemolytic anemia? How do I determine the cause of hemolytic anemia? When should I investigate for hemoglobinopathy? What factors suggest the need for bone marrow examination? What is the most effective way to administer oral iron? When and how should I use erythropoietin (EPO) in anemia of renal dysfunction or anemia of chronic disease? (How is it dosed and when should I expect a response?)Polycythemia and Secondary Erythrocytosis How do I distinguish primary and secondary erythrocytosis in a patient who smokes or has chronic lung disease? When should I be concerned about carbon monoxide poisoning? How do I manage secondary erythrocytosis? What tests should I do to rule out a myeloproliferative disorder? What complications can occur in patients with myeloproliferative disorders? When is phlebotomy indicated? How frequently should phlebotomy be performed and what are the monitoring parameters? Is there a role for antiplatelet agents and anticoagulants in patients with a myeloproliferative disorder?Thalassemia and Hemoglobinopathies Which hemoglobinopathies are considered to be clinically significant? How is thalassemia differentiated from iron deficiency anemia? When should one investigate for hemoglobinopathies? When should transfusion therapy be considered? What are the common complications in patients with thalassemia?Sickle Cell Disease What are triggers for admission in a patient with sickle cell disease? What is appropriate hydration for acute chest syndrome or painful crisis? What clinical presentations benefit from red blood cell transfusion or red cell exchange? What is an appropriate transfusion threshold? How is pain optimally managed? What are special considerations in management of sickle cell disease in pregnancy or in labor? What are special considerations perioperatively? When should hydroxyurea be used? SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1137617559 ER -